منابع مشابه
Lactate Metabolism is Associated with Mammalian Mitochondria
It is well established that lactate secreted by fermenting cells can be oxidized or used as a gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that within the fermenting cell itself, lactate is produced to replenish NAD+ and then is secreted. Here we explore the possibility that cytosolic lactate is metabolized by the mitochondria of fermenting mammalian cel...
متن کاملCarbohydrate and Lactate Metabolism
Van Hall, G., J. A. L. Calbet, H. Søndergaard, and B. Saltin. Similar carbohydrate but enhanced lactate utilization during exercise after 9 wk of acclimatization to 5,620 m. Am J Physiol Endocrinol Metab 283: E1203–E1213, 2002. First published July 30, 2002; 10.1152/ajpendo. 00134.2001.—We hypothesized that reliance on lactate as a means of energy distribution is higher after a prolonged period...
متن کاملLactate oxidation in human skeletal muscle mitochondria.
Lactate is an important intermediate metabolite in human bioenergetics and is oxidized in many different tissues including the heart, brain, kidney, adipose tissue, liver, and skeletal muscle. The mechanism(s) explaining the metabolism of lactate in these tissues, however, remains unclear. Here, we analyze the ability of skeletal muscle to respire lactate by using an in situ mitochondrial prepa...
متن کاملLactate metabolism by Veillonella parvula.
A strain of Veillonella parvula M4, which grows readily in lactate broth without a requirement for carbon dioxide, has been isolated from the oral cavity. Anaerobic, washed cells of this organism fermented sodium lactate to the following products (moles/100 moles of lactate): propionate, 66; acetate, 40; carbon dioxide, 40; and hydrogen, 14. Cells grew readily in tryptone-yeast extract broth wi...
متن کاملMitochondria: Redox Metabolism and Dysfunction
Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of the underlying causal factors for a variety of diseases including neurodegenerative diseases, dia...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2008
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2008.09.042